- E-IDE Enhanced Integrated Drive Electronics
- EAP Enterprise Architecture Planning
- EARN European Academic and Research Network
- EAROM Electronically Alterable Read Only Memory
- EB Enable Button
- EBCDIC Extended-Binary-Coded Decimal Interchange Code
- EBIOS Extended BIOS
- ECC Error Checking and Correcting
- ECCs Error Correction Codes
- ECD Energy Conversion Devices
- ECL End Communication Layer
- ECMA European Computer Manufacturers Association
- ECP Extended Capability Port
- ECSA Exchange Carriers Standards Association
- ED Extended Disk
- EDC Error Detection Code
- EDI Electronic Data Interchange
- EDL Edit Decision List
- EDLIN EDitor of LINes
- EDM End Of Message
- EDO Extended Data Out
- EE Extended Edition
- EEPROM Electronically Erasable Programmable Read-Only Memory
- EFF Electronic Frontier Foundation
- EFLA Extended Four-Letter Acronym
- EGA Enhanced Graphics Array / Exterior Gateway Protocol
- EGP Exterior Gateway Protocol
- EI Enable Item
- EIA Electronics Industries Association
- EIA/TIA Electronic Industries Association/Telecommunication / Industries Association
- EIS Executive Information System
- EISA Extended Industry Standard Architecture
- EL ElectroLuminescent
- ELAP EtherTalk Link Access Protocol
- ELF Extremely Low Frequency Radiation
- EM Expanded Memory
- EMACS Editor MACroS
- EMI Electro-Magnetic Interference
- EMM Expanded Memory Manager
- EMS Extended Memory System / Expanded Memory Specification
- EMWAC European Microsoft Windows NT Academic Consortium
- ENIAC Electronic Numerical Integrator And Calculator
- EOF End Of File
- EOI End Of Interrupt
- EOT End Of Transmission
- EP Execute Program
- EPA Environmental Protection Agency
- EPP Enhanced Parallel Port
- EPROM Erasable Programmable Read-Only Memory
- EPS Encapsulated PostScript
- EPSF Encapsulated PostScript File
- ES-IS End System to Intermediate System Protocol
- ESC Educational Software Cooperative
- ESCD Extended System Configuration Data
- ESD ElectroStatic Discharge
- ESDI Enhanced Small Device Interface
- ESF Extended Superframe Format
- ETLA Extended Three-Letter Acronym
- ew embedded window